Entomologist Colt left the firm of his ex Vicky's dad Russ and his ruthless partner Gary, in order to regain his scientific independence and ethical virginity. After people are found on several founds with strange bite-marks, which turn out to be the work genetically miss-manipulated locusts, Colt teams up again with Vicky, who works for the public health authorities. After analyzing the facts, they join the heroic, possibly hopeless fight to stop the locust swarm spreading and endangering millions in most of Northern America.

In 1966, somewhere in Russia, a wounded woman drives a truck to an isolated farm with two babies. Forty years later, the film producer Marie Jones leaves her daughter in California and travels back to her home land in the wilderness of Russia. Marie is one of the children and had received a phone call from the notary public Andrei Misharin that had told her where the farm of her family is. Marie arrives in the abandoned house and meets the stranger Nicolai that tells her that he had also received a call from Misharin and he is her twin brother. Weird things happen in the house and Marie and Nicolai are haunted by eerie ghosts of themselves. Further, they find that they are trapped in the house and can not leave the place.